Infection Are Superantigen Independent Initial Stages of Mammary Tumor Virus
نویسندگان
چکیده
منابع مشابه
Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection.
Mouse mammary tumor virus (MMTV) is a milk-borne betaretrovirus that has developed strategies to exploit and subvert the host immune system. Here, we show in a natural model of MMTV infection that the virus causes early and progressive increases in superantigen (SAg)-specific Foxp3(+) regulatory T cells (T(reg)) in Peyer's patches (PP). These increases were shown to be dependent on the presence...
متن کاملSuperantigen-reactive CD4+ T cells are required to stimulate B cells after infection with mouse mammary tumor virus
Superantigens are defined by their ability to stimulate a large fraction of T cells via interaction with the T cell receptor (TCR) V beta domain. Endogenous superantigens, classically termed minor lymphocyte-stimulating (Mls) antigens, were recently identified as products of open reading frames (ORF) in integrated proviral copies of mouse mammary tumor virus (MMTV). We have described an infecti...
متن کاملB cell response after MMTV infection: extrafollicular plasmablasts represent the main infected population and can transmit viral infection.
The immune response to mouse mammary tumor virus (MMTV) relies on the presentation of an MMTV-encoded superantigen by infected B cells to superantigen-specific T cells. The initial extrafollicular B cell differentiation involved the generation of B cells expressing low levels of B220. These B220low B cells corresponded to plasmablasts that expressed high levels of CD43 and syndecan-1 and were C...
متن کاملRegions of mouse mammary tumor virus superantigen involved in interaction with the major histocompatibility complex class II I-A molecule.
To study the major histocompatibility complex class II I-E dependence of mouse mammary tumor virus (MMTV) superantigens, we constructed hybrids between the I-E-dependent MMTV(GR) and the I-E-independent mtv-7 superantigens and tested them in vivo. Our results suggest that, although the C-terminal third mediates I-A interaction, additional binding sites are located elsewhere in the superantigen.
متن کاملPreactivation of B lymphocytes does not enhance mouse mammary tumor virus infection.
We investigated whether mouse mammary tumor virus (MMTV) favors preactivated or naive B cells as targets for efficient infection. We have demonstrated previously that MMTV activates B cells upon infection. Here, we show that polyclonal activation of B cells leads instead to lower infection levels and attenuated superantigen-specific T-cell responses in vivo. This indicates that naive small rest...
متن کامل